Peer-Reviewed Science

Re-inventing Biology

Microbiome science, decoded from the guts of elite athletes to fundamentally change how we optimize our bodies.

Nature Medicine · 2019
Microbiome Journal · 2022
iScience · 2023
medRxiv Preprint · 2025
Explore the science
Why This Matters

Bacteria sourced from the finest microbiomes on the Earth

You can't see your microbiome, so it's easy to ignore. But it's quietly involved in your sleep, your energy, your digestion, and how fast you recover. Here's the problem we set out to solve, what we found, and why it matters even if you've never run a marathon.

Translating Biology
The Problem

Modern life quietly wrecks your gut bacteria.

Processed food, stress, poor sleep, antibiotics, and sendentary lifestyles all reshape your microbiome — usually for the worse. The result shows up as fatigue, restless sleep, sluggish digestion, and slower recovery, but almost nobody connects those symptoms back to their gut.

The Discovery

Elite athletes' guts held the answer.

Researchers from Wyss Institute sequenced the gut microbiomes of ultra-marathoners before and after the race. Specific bacterial strains spiked after finishing - strains that were nearly absent in sedentary people. Those strains became the secret to your longevity journey.

Why It Helps

You don't need to be elite to benefit.

These strains occur naturally in the human body — we didn't engineer them, we found them. That means supplementing with them works with your existing biology instead of against it, whether you run marathons or just want to feel less tired.

Microbiome 101

You have 39 trillion microbial roommates.
Most people are ignoring them.

Your gut microbiome is a living ecosystem of bacteria — roughly 39 trillion microorganisms that outnumber your human cells. Together, they encode 150× more unique genes than your own genome and 90% of your short-chain fatty acids, operating as a second brain that influences nearly every aspect of your health.

These microbes aren't passive residents — they actively produce neurotransmitters, regulate immune function, synthesize vitamins, and convert dietary compounds into bioactive metabolites your cells use as fuel. Veillonella atypica, the bacterium at the core of V·Nella, does exactly that: it takes lactic acid — the byproduct of intense exercise — and converts it into propionate, a short-chain fatty acid that re-enters your mitochondria as usable energy.

The problem: modern life — processed food, chronic stress, poor sleep, antibiotics — systematically depletes the high-performance strains found in fit individuals. The result is fatigue, slow recovery, disrupted sleep, and blunted cognition that most people attribute to "just getting older."

150×
more genes than
human genome
39T
microorganisms
in your gut
70%
of immune system
lives in your gut
Microbiome 101
Lactate Metabolism

Your lactic acid isn't waste.
V·Nella turns it into fuel.

During exercise, your muscles produce lactate — a byproduct of anaerobic glycolysis. In most people, excess lactate accumulates, triggering fatigue, muscle burn, and slower recovery. But our researchers discovered something remarkable: elite endurance athletes carry high abundances of Veillonella atypica, a microbe that metabolizes lactate into propionate — a short-chain fatty acid (SCFA) with profound systemic effects.

Propionate re-enters your bloodstream and acts across multiple organ systems. It fuels mitochondria directly, activates the vagus nerve to signal the brain, reduces systemic inflammation, and promotes lean muscle recovery. Initial results were published in Nature Medicine, with further studies showing supplementation with Veillonella atypica leads to 52 more days without fatigue interfering in the span of a year vs. controls — without any change in training.

+52 days
Without fatigue interfering in the span of a year
Improved run-until-exhaustion in pre-clinical trial
+2 extra hours
Voluntary exercise compared to personal baseline
Lactate Metabolism

4000+ peer-reviewed studies have investigated propionate and other short-chain fatty acids, linking them to mitochondrial metabolism, immune regulation, inflammation, gut barrier function, and metabolic health. Emerging research also suggests roles in healthy aging and brain health.

The Science
Gut · Immune · Brain

You thought probiotics were just for your digestion.
Nella proves you wrong.

The gut-immune-brain axis is one of the most consequential and least understood pathways in human biology. Your gut microbiome doesn't just process food — it directly regulates immune tone, neurological signaling, and hormonal balance through your gut-immune-brain connection.

Nella's proprietary strains activates this axis, producing measurable reductions in reactive oxygen species (free radicals) — the cellular stress markers linked to accelerated aging, inflammation, and metabolic dysfunction. In clinical data, users experienced reductions in systemic inflammatory markers alongside improved sleep architecture and recovery.

Additionally, the gut microbiome plays a critical role in androgen metabolism. Optimizing microbial diversity has been associated with increased free testosterone bioavailability — a benefit that extends beyond athletes to anyone experiencing the hormonal shifts of aging.

↓ ROS
Reduces oxidative stress & free radical damage
↓ IL-6
Lowers pro-inflammatory cytokines systemically
↑ T-free
Supports free testosterone bioavailability
Gut Immune Brain

12,000+ peer-reviewed studies demonstrating continuous communication between the microbiome, immune system, and nervous system through microbial metabolites, immune signaling, and neural pathways.

The Science

Not all microbiome solutions are made equal.

We decoded the guts of ultra-marathon runners. See how we compare.

How V·Nella really compares.

Endurance, recovery & energy — measured against the supplements already in your routine.

V·Nella
V·Nella™
NADH
Urolithin A
Creatine
Caffeine
iSourced from Elite Biology
Ingredient-level only
Compound studied, not this product
Compound studied, not this product
Compound studied, not this product
iProprietary
iHuman Clinicals
Strain-dependent
iImproves Digestion
Aids regularity, may cause GI upset
iReduces Cellular Stress and Inflammation
Limited, indirect evidence
iBenefits You Can Feel

Comparisons reflect typical, publicly available product and ingredient information. Individual brands vary.

The difference? It's where the strains came from and whether anyone actually tested if they work. We can point to the athlete, the lab, and the published paper for both.

Peer-Reviewed Research

The published science behind every claim.

Each FitBiomics product is built on research that passed peer review and was published in leading scientific journals — not proprietary studies kept behind closed doors.

From the community who wanted to experience the biological upgrade.

Verified reviews from real customers.